Journal of Nutrition Animal Diets/Enrichment Products...

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Journal of Nutrition Vol. 29 No. 3 March 1945, pp. 191-199
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Niacin (Nicotinic Acid), an Essential Growth Factor for Rabbits Fed A Purified Diet

Five Figures

Jerald G. Wooley and W. H. Sebrell

Division of Physiology, National Institute of Health, U. S. Public Health Service, Bethesda, Maryland

conclusions

1. Young rabbits fed a purified ration supplemented with pure vitamin preparations grew at a nearly normal rate.
2. Rabbits fed this purified diet require niacin for survival and adequate growth.
3. Symptoms shown by rabbits receiving the niacin deficient diet are loss of weight and usually severe diarrhea 24 to 48 hours before death.
4. Rabbits fed the diet containing adequate amount of niacin but pair-fed with litter mates receiving the niacin deficient ration died as early as the deficient animals and showed simliar symptoms.
5. Rabbits fed the niacin deficient diet for 3 months or longer showed significantly less niacin in the voluntary muscles than the litter mates given niacin.


Manuscript received 30 September 1944.





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