QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kesten, H. D. Articles by Stetten, D. W. Search for Related Content PubMed Articles by Kesten, H. D. Articles by Stetten, D. W., Jr.

Fatal Myocarditis in Choline Deficient Rats Fed Ethyl Laurate¹

Four Figures

Department of Pathology and Biochemistry, College of Physicians and Surgeons, Columbia University, New York

The feeding of ethyl laurate, at a 35–40% level in the diet, to young rats receiving no choline resulted in death from heart failure in from 3 to 6 days. The pathological process was an acute diffuse interstitial myocarditis. It was preventable by the adequate administration of choline, betaine or methionine. The disease did not occur in rats fed the ethyl esters of other fatty acids and was not fatal when the quantity of ethyl laurate was reduced to 25% of the diet. Though histologically similar, the disease is apparently not identical with the myocarditis of potassium deficiency.

² William J. Gies Fellow, 1943–45; University of the Philippines Fellow, 1941–45.

Manuscript received 29 September 1944.