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Neuropathologic Studies of Pantothenic Acid, Biotin and Folic Acid Complex Deficiencies in the Chick¹

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. The deficiency of pantothenic acid in the chick caused a very widespread myelin and axon degeneration in the spinal cord. There was no accompanying degeneration in the peripheral nerves.

2. These lesions of the spinal cord occurred in pantothenic acid deficiency, whether it was produced on a very incomplete ration such as the heated ration or on an otherwise complete sucrose ration.

3. Complicating deficiencies which appeared on the heated ration did not seem to alter the neuropathologic lesions in a pantothenic acid deficiency.

4. No neuropathologic lesions were observed in chicks suffering from a mild biotin deficiency, or an acute deficiency of the folic acid complex.

We are indebted to Merck and Co., Rahway, New Jersey, for the synthetic vitamins and to Abbott Laboratories, North Chicago, Illinois, for the halibut liver oil.

We are also indebted to G. M. Briggs, Jr., and Harry A. Waisman who provided part of the chicks observed in these studies.

Manuscript received 11 August 1944.