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The Biological Assay of Vitamin A by Means of Its Influence on the Cellular Contents of the Vagina of Rats

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Laboratory of Hygiene, Department of Pensions and National Health, Ottawa, Canada

A method of biological assay of vitamin A and its precursors based on the changes produced in the cellular contents of the vagina of ovariectomized rats is described. The dosage response relationship was analysed by methods of variance and covariance and shown to be logarithmic. The method shows considerable advantage over the increase in weight method with respect to precision and economy of time, material and effort. The enhancement of the biological activity of vitamin A by tocopherols has been confirmed and a method of overcoming this effect in the estimation of vitamin A activity is described.