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Toxicity of Fractions of Hog Liver Fatty Acids to Chicks Fed a Vitamin E Deficient Diet¹

Two Figures

Departments of Anatomy and Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester, New York

Three fractions of hog liver fatty acids were tested for their effectiveness in producing exudative diathesis and encephalomalacia in chicks reared on a vitamin E deficient diet.

When fed as 4% supplements to the diet, the least unsaturated fraction (iodine value 5) had little effect and gave only exudates; the intermediate fraction (iodine value 104) gave both exudates and encephalomalacia, whereas the most unsaturated fraction (iodine value 241) caused a rapid onset of severe encephalomalacia and early death of the animals. The deleterious effect of this fraction could be prevented by d, 1-alpha-tocopherol acetate. When fed in smaller amounts corresponding to 0.5–0.6% of the diet, the most unsaturated fraction gave both exudates and encephalomalacia.

The significance of the incorporation of dietary fatty acids in tissue lipids as a prerequisite to the symptoms is discussed.

Manuscript received 16 May 1944.

This article has been cited by other articles:

				B. CENTURY, M. K. HORWITT, and P. BAILEY Lipid Factors in the Production of Enephalomalacia in the Chick Arch Gen Psychiatry, October 1, 1959; 1(4): 420 - 424. [Abstract] [PDF]