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Ineffectiveness of Vitamin E in Preventing Cholesterol Deposition in the Aorta¹

Department of Anatomy and Biochemistry, University of Rochester, School of Medicine and Dentistry, Rochester, New York

1. Vitamin E, fed as 10 mg. % d, l-alpha-tocopherol acetate in the basal diet, failed to modify the deposition of cholesterol in the aorta in (a) rabbits fed a diet of ground oats and carrots plus 1% cholesterol, and in (b) chicks fed an artificial diet deficient in vitamin E and containing 30% lard and 2% cholesterol, with or without addition of 1.5% inositol or 2% lipocaic.

2. The vitamin E supplement prevented a high mortality occurring in rabbits fed the oats-carrots-cholesterol diet, reduced the normal cholesterol content of muscles in chicks fed the basal artificial diet, and the increased muscle cholesterol of chicks fed the same diet supplemented with 2% cholesterol; the explanation of these effects is obscure.

3. In chicks inositol feeding reduced, and lipocaic feeding increased, the extensive deposition of liver cholesterol following additions of the latter to the basal diet.

Manuscript received 16 May 1944.