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Journal of Nutrition Vol. 28 No. 4 October 1944, pp. 283-288
Copyright © 1944 by American Society for Nutrition
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Absence of Nerve Degeneration in Chronic Thiamine Deficiency in Pigs1

One Figure

Maxwell M. Wintrobe2, Richard H. Follis, Jr., Stewart Humphreys2, Harold Stein and Marjorie Lauritsen2

Department of Medicine, Johns Hopkins University, Baltimore, Maryland

Additional experiments in pigs in which chronic thiamine deficiency was produced, have failed to support the claim that lack of thiamine causes degenerative changes in the nervous system.

It is pointed out that autoclaving destroys not only thiamine, but reduces the pantothenic acid content of yeast as well. It is suggested that certain effects heretofore attributed to lack of thiamine may have in reality been due to lack of pantothenic acid.

1 Aided by grants from the Rockefeller Foundation, Parke-Davis and Company, the Upjohn Company, and the Fleischmann Laboratories, and carried out in cooperation with the Bureau of Animal Industry, U. S. Department of Agriculture.

2 Present address, School of Medicine, University of Utah, Salt Lake City, Utah.

Manuscript received 18 April 1944.


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