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Inadequacy of Lactose and Beta-Lactose as Dietary Carbohydrates for the Rat

Emory W. Thurston Laboratories, Los Angeles, California, and the Department of Biochemistry and Nutrition, University of Southern California Medical School, Los Angeles, California

Male and female rats of the Long-Evans and U.S.C. strains were placed at weaning on purified rations containing lactose, beta-lactose, glucose, galactose, sucrose and corn starch as the sole source of carbohydrate. The following observations were made: (1) rats failed to survive on purified rations containing lactose or beta-lactose as the sole carbohydrate; (2) rats developed alopecia when fed the above lactose or beta-lactose rations; (3) a strain difference was observed in the incidence and degree of alopecia as well as the length of survival of rats fed lactose or beta-lactose rations; (4) rats fed a beta-lactose ration died sooner and developed more severe alopecia than those fed a lactose diet; (5) length of survival was correlated with severity of diarrhea; and (6) a relationship was observed between degree of mortality and previous maternal diet.