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Intestinal Absorption of Galactose in the Rat as Affected by Suboptimal Intakes of Thiamine^1,2,3,

One Figure

Department of Biochemistry, School of Medicine, Western Reserve University, Cleveland, Ohio

1. The rate of intestinal absorption of galactose was measured in 3 groups of rats which were kept for 70 to 80 days on thiamine intakes of 2 µg., 5 µg., and 10 µg. per day, respectively. The absorption was compared with "paired" control animals receiving 40 µg. of thiamine per day.

2. The rate of absorption of galactose in rats receiving these suboptimal thiamine intakes averaged 85% to 90% of that of the controls.

3. The methods employed did not indicate any change in the rate of metabolism of galactose as a result of the chronic thiamine deficiency.

² This investigation was supported by a grant from the Williams-Waterman Fund of the Research Corporation, New York.

³ We are indebted to Merck and Co., Rahway, New Jersey, for generous supplies of the vitamins employed in this study.

Manuscript received 24 April 1944.