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Journal of Nutrition Vol. 28 No. 3 September 1944, pp. 141-156
Copyright © 1944 by American Society for Nutrition
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Effect of the Composition of the Diet on the Riboflavin Requirement of the Rat1

G. J. Mannering, Demosthenes Orsini2 and C. A. Elvehjem

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

When the riboflavin intake is sub-optimal, rats receiving a diet rich in dextrin or cornstarch show greater weight increases than do animals receiving diets characterized by their content of sucrose, cellulose, lactose, or lard. Lactose is not entirely without effect in this respect.

The total fecal output of riboflavin of rats receiving various riboflavin-low diets has been determined, and in general, those carbohydrates which decrease the amount of dietary riboflavin needed by the rat for growth are also responsible for the greatest quantities of riboflavin in the feces. However, the fecal excretion of riboflavin was greatest when lactose was fed, although the growth-promoting effect of lactose was not great.

The relationship between growth, cecal size, intestinal synthesis, and the quantity of riboflavin in the cecum and feces is discussed.

The feeding of high levels of dietary fat to riboflavin deficient rats results in a spastic paralysis of the hind quarters, a condition not noted with any degree of severity when riboflavin-low rations of high carbohydrate content are employed. Riboflavin deficient rats survive for shorter periods of time when fed a high fat ration than when maintained on a high carbohydrate diet.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. This work was supported in part by grants from Commercial Solvents Corporation, and the Research Funds of the University.

We are indebted to Merck and Company, Rahway, New Jersey, for the synthetic vitamins; to Abbott Laboratories, North Chicago, Illinois, for haliver oil; and to Wilson Laboratories, Chicago, Illinois, for liver extracts.

2 Rockefeller Fellow. Present address, Sao Paulo Medical School, San Paulo, Brazil.

Manuscript received 10 April 1944.




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