QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Reinhold, J. G. Articles by Chornock, C. Search for Related Content PubMed Articles by Reinhold, J. G. Articles by Chornock, C.

The Utilization of Thiamine in the Human Subject: The Effect of High Intake of Carbohydrate or of Fat¹

Three Figures

Gastro-Intestinal Section (Kinsey-Thomas Foundation) of the Medical Clinic, University of Pennsylvania Hospital, and from the Philadelphia General Hospital, Philadelphia

1. The urinary excretion of thiamine was decreased in five out of six women when the carbohydrate-fat ratio in the diet was increased, all other dietary and environmental factors remaining constant. The decrease in thiamine excretion was manifested by interruption of a rising trend of excretion in four subjects and by a decrease in mean excretion in one.

2. No evidence of a "thiamine-sparing action" of fat was observed.

3. Excretion of free and total thiamine in the feces was not significantly affected by changes in carbohydrate-fat ratio of the diet.

4. The present observations demonstrate that the amount of carbohydrate in the diet is an important factor in determining the daily human requirement for thiamine.

Manuscript received 8 December 1943.