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Congenital Malformations Induced in Rats by Maternal Nutritional Deficiency

VI. The Preventive Factor¹

The Children’s Hospital Research Foundation, Department of Pediatrics, College of Medicine, University of Cincinnati, Ohio

1. The congenital malformations of the pattern of diet I are prevented when the maternal diet I is supplemented by riboflavin.

2. Supplements of thiamine hydrochloride, niacin, pyridoxine and calcium pantothenate are not preventive.

3. On a purified maternal diet in which the vitamin B-complex is represented by crystalline substances, malformations of the pattern of diet I appear in the offspring when riboflavin is omitted.

4. On the same diet supplemented by sufficient riboflavin no deformed offspring are observed.

5. It is concluded that a deficiency of the maternal diet in riboflavin is responsible for the congenital malformations of the pattern of diet I.

Manuscript received 1 February 1944.

This article has been cited by other articles:

				J. WARKANY and E. SCHRAFFENBERGER CONGENITAL MALFORMATIONS INDUCED IN RATS BY MATERNAL VITAMIN A DEFICIENCY: I. Defects of the Eye Arch Ophthalmol, February 1, 1946; 35(2): 150 - 169. [Abstract] [PDF]