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Journal of Nutrition Vol. 27 No. 6 June 1944, pp. 469-476
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The Bioassay of Vitamin E1

One Figures

Gladys A. Emerson and Herbert M. Evans

Institute of Experimental Biology, University of California, Berkeley

A comparison was made of the standard lard cod liver oil containing diet with rations composed of vitamin E free ingredients.

During the period of early growth the rats receiving the high fat ration grew at a more rapid rate than did their sisters maintained on the low fat diets, but after several months significant differences were not apparent. The rats receiving a diet supplemented with brewers' yeast attained a slightly higher weight plateau than did the rats receiving extracted brewers' yeast.

The highest incidence of first litter fertility was observed with rats maintained on the high fat diet; nevertheless, the rats maintained on this ration were less sensitive as test animals for vitamin E assays than were rats raised on the extracted diets. Unextracted yeast can be employed to advantage in vitamin E low rations. Peanut oil may replace ethyl linoleate as a vitamin E free source of the essential fatty acids.

Multiple, as contrasted with single dosage of alpha-tocopherol, appeared to result in a higher percentage of litters.

Virgin and resorption gestation rats served equally well as test animals. First litter fertility was encountered if the trial gestations were initiated at 60 days, but not at 110 days.

The minimal effective level of alpha-tocopheryl acetate to insure fertility in rats maintained on the high fat standard ration is between 1.8 and 2.7 mg.

1 Aided by grants from the Board of Research and from the Department of Agriculture of the University of California, and the Rockefeller Foundation, New York City. The following materials were generously contributed: natural alpha-tocopherol by Merck and Company, Inc., Rahway, New Jersey; alpha-tocopheryl acetate by the League of Nations Committee on Vitamin Standardization; yeast by the Vitamin Food Company, New York; and calciferol by the Withrop Chemical Company, Rensselaer, New York.

Manuscript received 7 August 1943.




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