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Journal of Nutrition Vol. 26 No. 4 October 1943, pp. 391-398
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Factors Influencing the Bioassay of Vitamin E1

Bernard R. Homrich

Research Laboratories of General Mills, Inc., Minneapolis, Minnesota

The methodology of the vitamin E bioassay has been studied and it has been noted that the assay results are improved by discarding rats having less than seven and more than fourteen implantations.

The lessened effectiveness of dosing prior to mating was demonstrated.

Autopsy of the assay rats prior to parturition eliminates possible errors due to infanticide.

The high rate of pseudopregnancies (10 to 20%) reported by other workers was not experienced.

The vitamin E activity of an assay sample is influenced by the presence of 22% lard and 2% cod liver oil in the basal diet during the dosing period. The use of a fat-free basal diet during the dosing period results in much higher live litter and live implantation efficiencies.

1 Paper no. 47, Journal Series, General Mills, Inc., Chemical Research Department.

Manuscript received 8 March 1943.




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