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The Role of Biotin and "Folic Acid" in the Nutrition of the Rhesus Monkey¹

Four Figures

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. The nutritional failure which results in monkeys fed a "synthetic" diet plus eight crystalline members of the B group of vitamins and ascorbic acid can be readily cured or prevented by the feeding of a norite eluate fraction of liver, also called "folic acid".

2. Normal growth is observed in monkeys given only the "folic acid" concentrate in addition to the basal diet and the nine crystalline vitamins.

3. The leucopenia in the deficient monkeys is quickly alleviated by the administration of the "folic acid" preparation.

4. Monkeys kept on 1 or 3% solubilized liver for long periods show loss of hair and nearly complete denudation together with a slight dermatitis and "porphyrin-like" secretion on the skin. These changes are alleviated by the administration of biotin.

5. Biotin has no growth-stimulating properties under the experimental conditions described.

We are indebted to Merck and Co., Rahway, New Jersey, for the synthetic vitamins; to Abbott Laboratories, North Chicago, Ill. for halibut liver oil; and to Wilson Laboratories, Chicago, Ill. for the various liver products.

Manuscript received 9 April 1943.

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