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The Utilization of d-Glucono--Lactone by the Organism of the Young White Rat

Department of Biological Chemistry, Medical School, University of Michigan, Ann Arbor

Young white rats were fed a diet whose limiting factor was an inadequate caloric value. When this basal diet was supplemented by either glucose or d-glucono--lactone as a source of additional calories, growth at a rate definitely greater than that of animals fed the basal low-caloric diet was observed. Glucose and the gluconolactone were almost equally effective in the promotion of growth. These studies are believed to indicate that under the conditions of the present experiments, gluconolactone in limited amounts may serve as a source of energy, utilization being effected either by direct oxidation or by conversion to glucose and oxidation of the latter.