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Anti-Acrodynic Potency of Seed Oils^1,2,

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. Twenty-four seed oils of known linoleic and linolenic acid content were assayed for their potency in the cure of rat acrodynia.

2. The anti-acrodynic potency of the oils was found to be in direct proportion to their linoleic acid content unless they contained considerable amounts of linolenic acid.

3. When linolenic acid was present the curative effect of the oils was greatly reduced. Isolated data on marine oils suggest that other lipids besides linolenic acid also produce this effect.

4. When linolenic acid was absent, or when it was present only in minor proportions, a daily dose equivalent to 12 mg. of linoleic acid cured the acrodynia; 4 mg. was not curative.

² We express our appreciation to The Lever Brothers Company for a grant in support of this work.

Manuscript received 19 March 1943.