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The Inadequacy of Eight Synthetic B Vitamins for the Nutrition of Puppies—Unknown Factor (Factors) in Yeast and Probably Liver^1,2,

One Figure

Department of Vital Economics, University of Rochester, New York

Puppies were fed synthetic diets supplemented with a synthetic vitamin B-complex with or without additional vitaminrich concentrates.

The young dogs receiving the synthetic vitamin B-complex containing only thiamine chloride hydrochloride, riboflavin, nicotinic acid, Ca-d-pantothenate, pyridoxine, choline, inositol and p-aminobenzoic acid developed varying degrees of dermatitis, loss of hair and general unhealthy skin and coat in 75 to 125 days, and died in 100 to 150 days.

If dry whole yeast or concentrates of yeast or liver were fed in addition to the crystalline vitamins the deficiency failed to appear.

² Supported in part by a grant from Standard Brands, Inc.

Manuscript received 13 March 1943.