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Journal of Nutrition Vol. 25 No. 6 June 1943, pp. 555-570
Copyright © 1943 by American Society for Nutrition
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The Role of "Folic Acid" and Biotin in the Nutrition of the Rat

A. D. Welch, Lemuel D. Wright and K. L. Sprague

Nutritional Laboratories, Medical Research Division, Sharp and Dohme, Inc., Glenolden, Pennsylvania

The inhibition of growth and increase in prothrombin time brought about by the inclusion of succinylsulfathiazole in highly purified rations adequate in the well-recognized members of the vitamin B complex could be largely overcome by supplements of a "folic acid" concentrate and crystalline biotin.

The relationship of "folic acid" and biotin to bacterial activity in the intestine is discussed.

Manuscript received 19 January 1943.




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