Journal of Nutrition

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Journal of Nutrition Vol. 25 No. 5 May 1943, pp. 497-502
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Growth in Mice Fed Diets Rendered Deficient in Cystine, but Not in Methionine1

Clifford D. Bauer and Clarence P. Berg

Biochemical Laboratory, State University of Iowa, Iowa City

Mice fed 14.7% of casein and 0.3% of cystine in diets complete in other factors grew slightly better than mice fed 18 or 32% of casein. When a hydrolysate of casein, deficient in cystine but not in methionine, was incorporated at a level of 14.8% in a diet along with 0.2% of tryptophane, it supported growth less well than when it was further supplemented with cystine or methionine, or both. Growth on the unsupplemented diet and its acceleration to the same extent by the addition of either cystine or methionine both suggest that the mouse is able to synthesize cystine when methionine is provided.

1 The experimental data in this paper are taken from a dissertation submitted by Clifford D. Bauer in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry in the Graduate College of the State University of Iowa.

Manuscript received 9 December 1942.




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