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The Effect of Pantothenic Acid on the Rate of Intestinal Absorption of Galactose in the Rat¹

Department of Biochemistry, School of Medicine, Western Reserve University, Cleveland, Ohio

The rate of intestinal absorption was measured in eighteen litter mate pairs of rats in which one member of the pair received a synthetic diet deficient in pantothenic acid and the other member received the same diet supplemented with 100 µg of calcium pantothenate daily. The rate of intestinal absorption of the pair-fed litter mate controls averaged 15% more than that of the deficient animals. One hour after the ingestion of the sugar blood galactose levels were essentially the same in both groups of rats.

Rats maintained on an adequate stock diet were supplemented with 300 µg. and 1000 µg. of calcium pantothenate daily. This supplementation of a normal diet with additional calcium pantothenate had no effect on the rate of intestinal absorption of galactose.

Manuscript received 2 December 1942.