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Journal of Nutrition Vol. 25 No. 4 April 1943, pp. 389-393
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The Effect of High Levels of Pantothenic Acid on Reproduction in the Rat and the Mouse

Alfred Taylor, Dorothy Pennington and Juanita Thacker

University of Texas, Biochemical Institute, and The Clayton Foundation for Research, Austin

Groups of breeding albino rats and mice of the dba strain were maintained on a commercial dog chow with and without a 100 µg. per gram supplement of calcium pantothenate.

During the course of the experiment fifty-eight control litters averaged 5.4 offspring per litter, and sixty litters produced by the animals on the vitamin enriched diet averaged 6.7 offspring per litter — an average increase of 24% for the latter.

A study of brain and heart weights in day-old rats produced by control and experimental groups indicated that the calcium pantothenate supplemented diet was associated with a relatively smaller brain and heart in the offspring.


Manuscript received 24 October 1942.





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