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Nutritional Dermatoses in the Rat

VIII. Vitamin A Deficiency¹

One Text Figure and Two Plates (Eleven Figures)

Department of Dermatology, Johns Hopkins University School of Medicine, and the Department of Biochemistry, Johns Hopkins University School of Hygiene and Public Health

1. When young rats were fed a diet deficient only in vitamin A insofar as it is now possible to concoct such a ration, there resulted a deficiency disease, the gross cutaneous signs of which differed from the previously accepted descriptions of vitamin A deficiency.

2. Complicating deficiencies of the vitamin B complex, fat and essential fatty acids were responsible for cutaneous alterations which resulted in the misrepresentation of the vitamin A deficiency syndrome.

3. The data obtained in this study indicate that the diets used hitherto for producing vitamin A deficiency in rats and the current United States Pharmacopoeia vitamin A assay diet should be revised when the objective is to obtain the picture of the uncomplicated deficiency.

Manuscript received 8 October 1942.