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Journal of Nutrition Vol. 25 No. 2 February 1943, pp. 185-196
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Renal Threshold for Ascorbic Acid in Twelve Normal Adults1

With a Note on the State of Tissue Reserves of Subjects on an Intake of Ascorbic Acid Approximating the Suggested Daily Allowance

One Figure

Jane Sanford Lewis, Clara A. Storvick, Hazel M. Hauck, Isabel Patterson, Shizuko Higano and Betty Hawthorne

New York State College of Home Economics and School of Nutrition, Cornell University, Ithaca and School of Home Economics, University of Washington, Seattle

Renal threshold values for ascorbic acid for twelve normal adults, four men and eight women, ranged from 1.1 to 1.8 mg. per cent. Values for ten of the twelve subjects were within a range of 1.1 to 1.3 mg. per cent.

Of six subjects receiving 74 mg. of ascorbic acid daily for from 12 to 14 days, three maintained tissue saturation if the excretion of half of the test dose in 24 hours is used as a criterion, whereas three gave evidence of slight depletion of tissue reserves of ascorbic acid on this intake.

1 Most of the data in this paper were included in theses presented to the faculty of the Graduate School of Cornell University in fulfillment of the requirement for the Ph.D. degree, June, 1941, by Clara A. Storvick, and for the M.S. degree, May, 1942, by Jane D. Sanford. Two subjects were studied by Clara A. Storvick at the University of Washington during 1941–1942.

Manuscript received 30 September 1942.




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