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Experiments Upon the Significance of Liberal Levels of Intake of Riboflavin

Department of Chemistry, Columbia University, New York

Experiments with diets (I, II, and III), otherwise similar, which contained, respectively, 3, 6.5, and 10 µg. of riboflavin per gram of air-dry food mixture were extended through successive generations of laboratory rats. The first of these levels seemed amply to support adult vitality and length of life at the "plateau" of optimal nutritional status with reference to this vitamin. The threefold higher riboflavin intake level of diet III did, however, appear to confer added benefits upon the offspring of these experimental families, as shown by their somewhat more favorable growth when continued on the family diet and by their greater ability to withstand deprivation either of riboflavin or of thiamine.

Manuscript received 9 October 1942.