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Choline and Pyridoxine as Factors in Prevention of Epithelial Hyperplasia in the Forestomach of Rats Fed White Flour

Department of Laboratories, Henry Ford Hospital, Detroit, Michigan

Choline and pyridoxine are necessary to help maintain normal epithelium in the forestomach of rats fed diets in which cystine and white flour furnish the only source of protein. Calcium pantothenate does not improve such diets. Using results of preliminary work with taurocholic acid as a basis, it is suggested that regurgitated bile in the stomach may be an important cause of the lesions. It is also suggested that choline helps prevent regurgitation of bile by stimulating the smooth muscle of the intestinal tract.