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The Utilization for Hemoglobin Regeneration of the Iron in Salts Used in the Enrichment of Flour and Bread

Division of Animal Nutrition, University of Illinois, Urbana

The availability of the iron in sodium iron pyrophosphate, ferrum reductum and ferric phytate for hemoglobin regeneration in anemic rats was compared in paired-feeding experiments with that of ferric chloride. The total storage of iron in rats on the various test diets was also determined by carcass analysis. The results of the experiments, involving a total of thirty-five pairs of rats, would seem to justify the following conclusions:

1. When the intake of the basic low-iron diet, as well as the intake of iron in the iron-containing material under test, is equalized among comparative animals, valid comparisons may be obtained after 1 week of feeding.

2. A daily intake of 0.2 mg. of iron by young anemic rats is insufficient for maximum hemoglobin regeneration, but the difference in this respect between doses of 0.2 and 0.3 mg. of iron as ferric chloride becomes less as the feeding period is continued and may practically disappear in 3 weeks' time.

3. The iron of sodium iron pyrophosphate and of ferrum reductum is as well utilized for hemoglobin regeneration as the iron of ferric chloride.

4. The iron of ferric phytate is only about half as well utilized as the iron of ferric chloride.

5. Total iron retentions confirmed the results of hemoglobin regeneration in these comparative tests, though they did not provide as decisive evidence.

6. The low utilization of the iron in ferric phytate may explain the apparently low utilization of the iron of wheat, for which some additional evidence is offered.

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