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Inhibition of the Symbiotic Synthesis of B Complex Factors by Sulfonamides

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The Fleischmann Laboratories, Standard Brands Incorporated, and Department of Pathology, Cornell University Medical College, New York, N. Y.

The inclusion of 0.5% sulfaguanidine in the diet of rats fed the available crystalline factors of the B complex results in a depressed growth. This effect can be counteracted by feeding such natural sources of the B complex as yeast and yeast extract. It is also prevented by feeding the feces of rats kept on the same diet without sulfaguanidine. These findings indicate that the sulfaguanidine inhibits the bacterial synthesis of essential factors which are present in the natural B complex.

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				R. F. LIGHT, R. P. ALSCHER, and C. N. FREY VITAMIN A TOXICITY AND HYPOPROTHROMBINEMIA Science, September 8, 1944; 100(2593): 225 - 226. [PDF]