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Body Fats in Rat Acrodynia^1,2,

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

During the development of acrodynia in rats on a low-fat diet, the crude fatty acids decreased in amount but increased in iodine number.

The non-curative single supplements, pyridoxine and pantothenic acid, produced no significant alterations in the quality or quantity of fat.

Supplements which cured or alleviated the dermal symptoms, viz., linoleic ester, rice bran concentrate, or pyridoxine plus pantothenic acid, produced increases in total fat and decreases in iodine number.

Fatty acids from acrodynic rats or from rats which had been cured with rice bran concentrate did not cure acrodynia.

The studies did not reveal the mechanism through which pyridoxine, pantothenic acid and linoleic acid protect against acrodynia.

² The authors are indebted to Lever Brothers Company for a grant in support of this work.

Manuscript received 24 April 1942.