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Linoleic Acid, Pyridoxine and Pantothenic Acid in Rat Dermatitis^1,2,

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

Rat acrodynia was produced on a diet containing 0.003% of unsaturated fat. Various factors were tested for their curative action. Pantothenic acid did not even alleviate the symptoms. Pyridoxine produced temporary alleviation but did not effect a cure. Ethyl linolate cured the acrodynia. Amounts of linolate which were subcurative alone became curative when given with pyridoxine. Pantothenic acid together with pyridoxine improved the dermal condition, and linolate subsequently produced further improvement. The three compounds together cured the acrodynia but did not cure completely the scaly condition of the tail and hind-paws. The results indicate that an additional factor is involved.

In prophylactic tests neither pantothenic acid nor pyridoxine prevented the acrodynia but pyridoxine retarded the development of the dermal lesions. A lack of pyridoxine did not result in acrodynia when animals were fed both linoleic acid (corn oil) and pantothenic acid.

Sustained growth resulted only when all three supplements were fed.

² The authors are indebted to The Lever Brothers Company for a grant in support of this work.

Manuscript received 24 April 1942.