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Vitamin B1 (Thiamine) Requirement of Man1

Three Figures

Daniel Melnick

Food Research Laboratories, Long Island City, New York

On the basis of objective thiamine balance studies, the vitamin B1 requirement of the adult is estimated to be 350 µg. per 1000 calories. The recommended daily intake is regarded as 500 µg. per 1000 calories. Only 73% of the so-called normal subjects, who were not restricted as to choice of diet, excreted sufficient quantities of thiamine in the urine to pass all the thiamine clearance tests.

1 This investigation was begun while the author was Upjohn Fellow in Clinical Research at the University of Michigan. The present paper, summarizing studies conducted at the University Hospital, Ann Arbor, and at the Food Research Laboratories, was reported at the symposium of the American Institute of Nutrition on "Human Requirements for the Vitamins" (Boston, April 1, 1942).

Manuscript received 15 April 1942.


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