QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Melnick, D. Articles by Field, H. Search for Related Content PubMed Articles by Melnick, D. Articles by Field, H., Jr.

Thiamine Clearance as an Index of Nutritional Status¹

Four Figures

Department of Internal Medicine, University of Michigan, Ann Arbor

Four different thiamine clearance tests were conducted on each of thirty-seven normal and deficient adult subjects. These consisted of the measurement of the basal 24-hour urinary excretion of thiamine, the fasting 4-hour excretion of the vitamin, the response to the oral administration of 5 mg. of thiamine and the 4-hour excretion of the vitamin when 350 µg. per square meter of body area are administered parenterally. Plotting the results of these tests, one against the other, gave good correlation. The numerous advantages in the use of the parenteral test dose procedure make it the method of choice for studying clinical cases. All normal subjects, but none of the deficient individuals, excreted in excess of 50 µg. of total thiamine during the 4-hour period following dosage.

² Upjohn Fellow in Clinical Research, 1937–1940. Now at the Food Research Laboratories, Long Island City, N. Y.

Manuscript received 15 April 1942.

This article has been cited by other articles:

				P. J. NANAGAS NUTRITIONAL DYSTROPHY OF THE CORNEAL EPITHELIUM: Report of Additional Cases with Biochemical Examinations Arch Ophthalmol, April 1, 1954; 51(4): 456 - 466. [Abstract] [PDF]

				J. B. YOUMANS DEFICIENCIES OF THE WATER-SOLUBLE VITAMINS JAMA, September 23, 1950; 144(4): 307 - 314. [Abstract] [PDF]

				THIAMINE REQUIREMENT OF MAN JAMA, January 2, 1943; 121(1): 53 - 53. [Abstract] [PDF]