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Storage of Pyridoxine in the Rat¹

Department of Chemistry, Fordham University, New York

The storage capacity for pyridoxine has been studied on young rats maintained on a vitamin B complex free diet supplemented with thiamine, riboflavin, and liver filtrate (or pantothenic acid).

If the rats are weanlings, they develop dermatitis in about 1 month; if they are allowed to subsist on the stock diet before being fed the pyridoxine-free ration, dermatitis does not develop until after 2 months. If the mother is given the B₆-free diet during the latter part of the lactation period, the young grow more slowly and symptoms of B₆ deficiency appear earlier than otherwise. Depleted animals given stated amounts of pyridoxine over a 10-day period show a progressive increase in rate of growth and corresponding delay in onset of dermatitis correlated with the amount of the vitamin given.

These data suggest that the irregularity in the occurrence of dermatitis in rats deprived of pyridoxine (reported by several workers) may be ascribed, at least in part, to differences in the reserves of the vitamin present in the young animals at the beginning of the experiment.

Manuscript received 28 February 1942.