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Serum Phosphatase in Experimental Scurvy

Two Figures

Department of Pediatrics, Harvard Medical School, Infants' and The Children's Hospitals, Boston, and Laboratories of Biochemistry, Department of Biology and Public Health, Massachusetts Institute of Technology

1. Guinea pigs fed a scorbutogenic diet show an immediate and continued decline in "alkaline" serum phosphatase activity reaching extremely low levels.

2. Animals (rabbits) able to synthesize ascorbic acid show no decline in serum alkaline phosphatase when fed a scorbutogenic diet.

3. Scorbutic guinea pigs fed a scorbutogenic diet supplemented by from 0.25–12.0 mg. ascorbic acid daily show rapid increases in serum alkaline phosphatase activity and rapid decreases when ascorbic acid is withdrawn.

4. Ascorbic acid does not activate the low serum phosphatase of scorbutic guinea pigs in vitro. The effect in vivo is due to an increase in enzyme production during recovery from scurvy.

5. There is no apparent change in serum "acid" phosphatase or in the serum inorganic phosphate of scorbutic guinea pigs.

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