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Antirachitic Properties of A.T. 10 for the Rat and Chicken

Research Laboratories, The Upjohn Company, Kalamazoo, Michigan

1. A.T. 10 has an antirachitic potency of 30,000 I.U. per gram as assayed by the U.S.P. XI rat technique.

2. A minimum protective level of A.T. 10 against rickets for chicks is around 6 I.U. of antirachitic activity per 100 gm. of ration. A toxic level is apparently about five times this dose.

3. By weight comparison A.T. 10 is approximately one-eighth as potent an antirachitic for chicks as vitamin D₂. However, on a rat unit basis, A.T. 10 is nearly 200 times more effective than vitamin D₂.

4. Rat unit for rat unit, A.T. 10 is about four times more powerful an antirachitic on the chick than vitamin D from cod liver oil. This is the first time an antirachitic substance of supposedly vegetable origin has demonstrated in chickens anywhere near the rickets preventive ability of vitamin D from cod liver oil when compared on a rat unit basis.

5. Under the conditions of these experiments the action of A.T. 10 resembles that of vitamin D rather than parathyroid hormone.