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The Inactivation of Vitamin B₁ in Diets Containing Whole Fish

Two Figures

Department of Bacteriology and Immunology, University of Minnesota, Minneapolis; Fromm Laboratories, Grafton, Wisconsin, and Division of Game and Fish, Minnesota State Department of Conservation

1. Among foxes fed a ration containing 20% whole carp and variable amounts of thiamine, Chastek paralysis failed to develop in those given 10 mg. of thiamine each day, and manifested itself only as transient anorexia among those given 5 mg. of thiamine. The onset of Chastek paralysis was delayed 1 month among foxes given 2 mg. of thiamine hydrochloride each day, and then appeared in this group in the usual fatal form.

2. A group of foxes fed skin, scales, fins, skeletons and heads of carp developed Chastek paralysis; another group fed the carp viscera contracted the disease; those given muscle as carp fillets showed no evidence of Chastek paralysis.

3. Observation on fur ranches where fish has been used indicates that Chastek paralysis will not develop if whole fish is fed several days a week and a diet containing adequate amounts of vitamin B₁ is fed on the other days of the week.

² Fromm Laboratories, Inc., Grafton, Wisconsin.

³ Cooperative investigations of Minnesota Department of Conservation and the University of Minnesota.

Manuscript received 22 August 1941.

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