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Journal of Nutrition Vol. 23 No. 1 January 1942, pp. 47-58
Copyright © 1942 by American Society for Nutrition
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Pantothenic Acid in the Nutrition of the Rat1

L. M. Henderson, J. M. McIntire, Harry A. Waisman and C. A. Elvehjem

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

Rats fed a synthetic ration deficient in pantothenic acid became gray in 4–6 weeks. Levels of calcium pantothenate above 40 µg. per day prevented or cured this condition. The rate of growth paralleled the level of pantothenic acid intake up to 80 µg. per day. Studies on the urinary excretion of this vitamin indicated that the daily requirement for the growing rat is approximately 100 µg. of calcium pantothenate per day.

Rats fed a heated grain ration showed graying which was likewise prevented and cured with synthetic calcium pantothenate. Copper deficiency caused a graying which did not respond to pantothenic acid but was rapidly cured by administration of copper.

Feeding hydroquinone failed to produce graying in rats receiving synthetic or milk rations. p-Aminobenzoic acid was entirely ineffective against the graying produced in rats by feeding a synthetic ration under our experimental condition.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by a grant from the National Live Stock and Meat Board made through the National Research Council. Technical assistance was supplied in part by a grant from the Works Progress Administration.

Manuscript received 26 August 1941.




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