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Dietary Requirements for Fertility and Lactation

XXIX. The Existence of a New Dietary Factor Essential for Lactation¹

Department of Agricultural Chemistry, University of Arkansas, Fayetteville

Young albino rats can exhibit excellent growth on diets in which the vitamin B complex was supplied by pure thiamine, riboflavin, pyridoxine, choline, pantothenic acid, nicotinic acid and "W" factor from liver extracts. Such diets with the amounts of these supplements greatly increased will not support either adequate reproduction or lactation. Experiments with new salt mixtures resulted in marked improvement in reproduction but lactation was still a failure. A rice bran extract and a liver extract were found to supply a factor, the presence of which resulted in 90% success in lactation. Tests with the ash of such products were negative; hence, the factor is organic. Para-aminobenzoic acid or a related compound is a component of the new factor tentatively designated "B_x"; preliminary tests suggest that inositol may also be a component.

Manuscript received 14 June 1941.