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-Tocopherol Requirement of the Rat for Reproduction in the Female and Prevention of Muscular Dystrophy in the Young

Departments of Biochemistry and Pathology, College of Physicians and Surgeons, Colubmia University, New York City

1. Under the experimental conditions described, 2.5 mg. of -tocopherol fed at the beginning of gestation permits the birth of young to at least 85% of female rats on vitamin E-low diets. The litters are of normal size (average 8.6 young), there are at least 85% of living young, 60% of which survive the first 10 days of lactation. Of the surviving rats, 90% develop muscular dystrophy at the end of lactation. Second litters are born to about one-fourth of the females.

2. Under the experimental conditions described, 0.5 mg. of -tocopherol fed on the fifteenth to the seventeenth day of lactation prevents muscular dystrophy in at least 85% of the young of female rats on vitamin E-low diets.

3. There are no essential differences in the anti-sterility and anti-muscular dystrophy preventing potencies between natural or synthetic -tocopherol or the synthetic acetate.

4. The -tocopherol must be fed as it is not so active when administered parenterally.

5. Muscular dystrophy may occur in the newborn rat.