QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Follis, R. H. Articles by McCollum, E. V. Search for Related Content PubMed Articles by Follis, R. H., Jr. Articles by McCollum, E. V.

Histological Studies of the Tissues of Rats Fed a Diet Extremely Low in Zinc¹

Two Plates (Eleven Figures)

Department of Pathology, School of Medicine, and Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland

In rats fed a diet adequate in all known respects except extremely low in zinc content, specific pathological changes were noted in the oesophagus, and to a lesser extent in the buccal cavity and the skin, and in a few animals, in the cornea.

The oesophagus showed extreme parakeratosis with a thick layer of partially keratinized cells.

The skin showed hyperkeratinization, thickening of the epidermis and loss of hair follicles with persistence of the sebaceous glands. Secondary bacterial infection occurred later.

The cornea of two animals showed vascularization and leucocytic infiltration similar to that which has been described in riboflavin deficiency. These ocular changes may indicate that zinc deficiency impairs the absorption or utilization of riboflavin.

² Present address: Department of Chemistry, Indiana University, Bloomington, Indiana.

Manuscript received 10 March 1941.

This article has been cited by other articles:

				A. S. PRASAD, A. MIALE JR., Z. FARID, H. H. SANDSTEAD, A. R. SCHULERT, and W. J. DARBY Biochemical Studies on Dwarfism,Hypogonadism, and Anemia Arch Intern Med, April 1, 1963; 111(4): 407 - 428. [Abstract] [PDF]

				W. BUSCHKE CLASSIFICATION OF EXPERIMENTAL CATARACTS IN THE RAT: RECENT OBSERVATIONS ON CATARACT ASSOCIATED WITH TRYPTOPHAN DEFICIENCY AND WITH SOME OTHER EXPERIMENTAL CONDITIONS Arch Ophthalmol, December 1, 1943; 30(6): 735 - 750. [Abstract] [PDF]

				M. E. SHILS and E. V. McCOLLUM HANDBOOK OF NUTRITION: IX: THE TRACE ELEMENTS IN NUTRITION JAMA, October 24, 1942; 120(8): 609 - 619. [Abstract] [PDF]