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Respiratory Metabolism in Fructosuria¹

One Figure

Department of Physiology, Cornell University Medical College, and the Biochemical Laboratory, Metropolitan Life Insurance Company, New York City

The effect of ingested fructose on the respiratory metabolism, the concentration of sugar and lactic acid in the blood, and fructose excretion have been determined in two fructosuric subjects.

The rapid initial rise in respiratory quotient, characteristic in the normal individual after fructose ingestion, was absent in both subjects. One subject responded with a slow rise in R.Q. similar to that after glucose. The other usually exhibited an increase in quotient only after a stimulating dose of fructose had been taken.

Blood and urine studies also were made of two other subjects. All failed to show the normal rise in blood lactate and excreted between 10 and 20% of the ingested fructose, in agreement with the reports of earlier investigators.

The two defects in fructose metabolism, diminished oxidation and absence of a significant rise in blood lactate, are discussed. It is suggested that the former may account for the observed fructosuria.

Manuscript received 15 November 1940.