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Studies on the Vitamin C Metabolism of Four Preschool Children¹

New York State College of Home Economics, Cornell University, Ithaca

Four preschool children were studied on various levels of ascorbic acid intake in an otherwise constant diet. After it was established that their tissues were saturated with vitamin C by checking their responses to test doses of 200 mg. of pure ascorbic acid, the level of intake was varied as follows: 115, 92, and 17 mg. were used for 1-week periods, and 66, 50, 43, and 31 mg. for 2-week periods. The 31 mg. level was repeated. Each period on a new level was followed by a test dose to recheck tissue saturation. The results of the study may be summarized as indicated below.

1. A daily intake of 31 mg. of ascorbic acid was the marginal level to insure tissue saturation in these four children.

2. The "utilization" of ascorbic acid was relatively constant at levels of intake from 31 to 50 mg. and the average value for these four children for four 2-week periods was 23±2 mg.

3. The per cent retention or "utilization" found in these children was lower than those reported in the literature for adults.

4. The requirement was not related to sex, age or body weight, at least within the limits found in these children.

Manuscript received 30 October 1940.

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				H. R. BUTT, W. V. LEARY, and R. M. WILDER DISEASES OF NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS Arch Intern Med, February 1, 1942; 69(2): 277 - 343. [Abstract] [PDF]