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Urinary Excretion of Thiamine on High Fat and High Carbohydrate Diets^1,2,

One Figure

Department of Physiological Chemistry, Wayne University College of Medicine, Detroit, Michigan

In an attempt to determine whether the carbohydrate content of the diet, like the thiamine content, influences the urinary output of thiamine, a study was made of the urinary thiamine excretion of adult individuals on comparable high fat and high carbohydrate diets. In all of the experiments reported it was found that even great alterations in the ratio of fat to carbohydrate in diets of the same thiamine content did not significantly affect the urinary thiamine excretion. This was true whether the thiamine intake was adequate or fairly low. A study of the excretion of thiamine administered orally after a period of depletion on comparable high fat and high carbohydrate diets also revealed no differential influence of fat or carbohydrate on the urinary thiamine output. The bearing of these findings on the validity of tests for thiamine deficiency which are based on a determination of the amount of thiamine excreted in the urine is pointed out.

² We wish to express our thanks to Dr. Richard M. Johnson, recent Medical Director of the Wm. J. Seymour Hospital at Eloise, Michigan, and at present Medical Director of Frederick Stearns and Company, Detroit, for providing us with some of the materials needed in this investigation.

Manuscript received 17 October 1940.

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				H. R. BUTT, W. V. LEARY, and R. M. WILDER DISEASES OF NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS Arch Intern Med, February 1, 1942; 69(2): 277 - 343. [Abstract] [PDF]