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Journal of Nutrition Vol. 21 No. 4 April 1941, pp. 341-346
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Arsenic and Goiter

George R. Sharpless and Margaret Metzger

Department of Laboratories, Henry Ford Hospital, Detroit, Michigan

1. Arsenic fed in non-toxic amounts (0.005% of the diet) had a slight, but not significant goiterogenic effect.
2. When the concentration of arsenic was 0.02% of the diet, growth was decreased 50%, iodine concentration of the thyroid was decreased and the thyroid weight was significantly increased.
3. Five times the minimum requirement of iodine when fed with 0.02% arsenic produced an enlargement of questionable significance, but lowered the thyroid iodine concentration.
4. It was calculated that 0.02% arsenic in the diet more than doubled the iodine requirement.

Manuscript received 26 October 1940.




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