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The Effect of Pyrazine Acids and Quinolinic Acid on the V-Factor¹ Content of Human Blood and Upon Canine Blacktongue

Four Figures

Department of Physiology and Pharmacology, Medical School, Duke University, Durham, North Carolina

1. Quinolinic acid, pyrazine monocarboxylic acid or pyrazine 2, 3-dicarboxylic acid taken orally by humans do not cause a rise in blood cell V-factor content.

2. None of the three acids caused a synthesis of V-factor when incubated under sterile conditions with defibrinated human blood.

3. None of the three acids was effective in curative trials on blacktongue. In preventive trials either 5 mg. quinolinic acid per kilogram, 10 mg. pyrazine monocarboxylic acid per kilogram or 4 mg. pyrazine dicarboxylic acid per kilogram daily was insufficient to prevent blacktongue, but 20 mg. quinolinic acid daily was preventive. These figures contrast with 0.15 mg. nicotinic acid daily, which is sufficient to prevent blacktongue.

Manuscript received 24 July 1940.

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