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The Prevention and Cure of Nutritional Muscular Dystrophy in the Rabbit by Alpha-Tocopherol in the Absence of a Water-Soluble Factor

Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland

1. We have been unable to confirm the report of Morgulis and co-workers that rabbits fed diet 13 require two factors for the structural integrity of their voluntary muscles. The muscular dystrophy produced on this diet has been prevented or cured by alpha-tocopherol without the addition of a water-soluble factor.

2. A quantitative relationship between alpha-tocopherol and a water-soluble factor could not be demonstrated.

3. Preventive and curative experiments place the average daily antidystrophy requirement of the rabbit for alphatocopherol between 0.6 and 1.0 mg. per kilogram of body weight.

4. The production of chronic dystrophy has been described and the symptoms discussed with reference to the action of vitamin E in the rabbit.