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Journal of Nutrition Vol. 18 No. 4 October 1939, pp. 411-421
Copyright © 1939 by American Society for Nutrition
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Simultaneous Appearance of a Positive Line Test and Radioactive Phosphate Deposition in the Rachitic Rat Metaphysis1

Four Figures and One Plate (Five Figures)

Kenneth Morgareidge2 and Marian LeFevre Manly3

Department of Biochemistry and Pharmacology, School of Medicine and Dentistry and The Institute of Optics, University of Rochester, New York

Following a single dose of Na2HPO4 containing the radioactive isotope (P32) accompanied by a single dose of vitamin D2, determinations have been made of the radioactive phosphorus content of whole blood and of the tibial diaphysis and metaphysis of rachitic rats. The data show that vitamin D has no influence on the entrance of phosphorus into the blood or into the diaphyseal portion of the tibia. In the metaphysis, however, the healing produced by the vitamin (as shown by the appearance of a positive line test) occurs concomitantly with a significant increase in the content of radioactive phosphorus. These effects in the metaphysis are seen only after the elapse of 54 to 72 hours subsequent to the administration of the vitamin. It is pointed out that the results support the conclusion that the mode of action of vitamin D is not limited to the control of intestinal absorption of the elements concerned in calcification.

1 These data are taken from a portion of the material presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy, University of Rochester, by Marian L. Manly.

2 Wisconsin Alumni Research Foundation graduate fellow in optics and biochemistry.

3 Rockefeller Assistant in isotope research.

Manuscript received 29 May 1939.


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