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Journal of Nutrition Vol. 17 No. 4 April 1939, pp. 371-382
Copyright © 1939 by American Society for Nutrition
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The Preventive Effect of Wheat Germ Oils and of {alpha}-Tocopherol in Nutritional Muscular Dystrophy of Young Rats1

Marianne Goettsch and Johana Ritzmann

Department of Biological Chemistry, College of Physicians and Surgeons, Columbia University, New York City

A diet is described on which 90% of rats at the end of lactation suddenly become affected with severe degeneration of the skeletal muscles.

A method is described for testing the protective effect of preparations against muscular dystrophy.

Young rats are protected against the muscle disease by supplementing the diet with wheat germ oil, with oil of treated wheat germ in which the anti-sterility vitamin has been inactivated by ethereal ferric chloride or with {alpha}-tocopherol.

The activity of a preparation in preventing muscular dystrophy does not necessarily correspond to its anti-sterility potency.

1 This work was aided by grants from the Rockefeller Foundation and the Carnegie Corporation of New York.

Manuscript received 14 December 1938.




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