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The Requirements of the Dog and the Rat for Nicotinic Acid

Three Figures

Department of Medicine, Western Reserve University and Lakeside Hospital, Cleveland, Ohio

Part I: The minimum dose of nicotinic acid necessary to protect the dog against blacktongue was found to be about 1.0 mg. per day for an animal of 5 to 10 kg. On a body weight basis 0.25 mg. of nicotinic acid per kilogram gave a rapid increase in weight and complete protection, 0.13 mg. per kilogram gave complete protection and a slight increase in weight, while 0.084 and 0.027 mg. per kilogram gave no protection. It has been calculated that 1.0 mg. of nicotinic acid is contained in 4 to 10 gm. of yeast.

Part II: Evidence is presented which indicates that nicotinic acid is not an essential substance for the rat.

Manuscript received 26 October 1938.