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The Utilization of Carbohydrate in Human Undernutrition^{1, 2,}

Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor

The oxidation of carbohydrate by normal human subjects has been studied in the respiration chamber following various degrees of depletion of the carbohydrate reserves. The failure to oxidize all the ingested carbohydrate appears to be related to the degree of depletion and will result when the depletion is severe enough even though the calories of the diet are significantly below the maintenance requirements of the subject.

Impairment of oxidation occurred when the stores were greatly reduced by sharp reduction of the intake of calories and carbohydrate. One might expect that the organism under these circumstances would oxidize all the incoming carbohydrate for energy purposes. On the contrary, it stores considerable portions, even though the energy expenditure far exceeds the intake. Apparently it is more important to replenish the carbohydrate stores than to use the incoming carbohydrate for fuel.

² A preliminary report of this work was presented at the meeting of the Society of Biological Chemists at Memphis, Tenn., April, 1937.

Manuscript received 25 October 1938.

This article has been cited by other articles:

				R. M. WILDER, H. C. BROWNE, and H. R. BUTT DISEASES OF METABOLISM AND NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS Arch Intern Med, February 1, 1940; 65(2): 390 - 460. [Abstract] [PDF]